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Question

In a post-transcriptional modification called tailing, ____ residues are added at the ____ of mRNA.

A
adenylate, 5'-end
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B
guanylate, 3'-end
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C
adenylate, 3'-end
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D
guanylate, 5'-end
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Solution

The correct option is C adenylate, 3'-end
After transcription (RNA synthesis from a DNA sequence), the precursor of messenger RNA (mRNA) called heterogenous nuclear RNA (hnRNA) undergoes modifications. One such modification is called tailing. In tailing, adenylate residues (200300) are added at 3'-end without any requirement of template. After modification, this fully processed hnRNA is now termed mRNA. It is then transported out of the nucleus for translation (protein synthesis from mRNA).

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BIOLOGY
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