Why are cimetidine and rantidine better antacids than sodium hydrogen carbonate or magnesium or aluminium hydroxide?

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Solution

Antacids $N a H C O_{3}, M g (O H)_{2} o r A l (O H)_{3}$ neutralize the excess acid produced in the stomach, but their prolong use can cause the prodution of excess acid in the stomach which is harmful and may result in ulcers, Cimetidine and rantidine work without such side effects as they prevent interaction of histamine with the receptores of the stomach wall as histamine stimulates the secretion of acid.

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Why are cimetidine and ranitidine better antacids than sodium hydrogen carbonate or magnesium or aluminium hydroxide?

Q. Between sodium hydrogen carbonate and magnesium hydroxide, which is a better antacid and why?

Which of the following compounds are administered as antacids?
(a) Sodium carbonate
(b) Sodium hydrogencarbonate
(c) Aluminium carbonate
(d) Magnesium hydroxide

Amongst the following antihistamines, which are antacids?
(a) Ranitidine
(b) Brompheniramine
(c) Terfenadine
(d) Cimetidine

Q. Assertion :Magnesium hydroxide is a better antacid than sodium hydrogencarbonate. Reason: Magnesium hydroxide being insoluble, it does not allow pH to increase above neutral, whereas hydrogen carbonate being soluble, its excess can make the stomach alkaline and trigger the production of even more acid.

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Antacids

Standard XII Chemistry

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