Gene Mutation

Q. What are the examples of Y-linked inheritance?

Q.

Ratio of WBC to RBC in human blood is

1. 1:100

2. 1:200

3. 500:1

4. 1:600

Q.

Is sickle cell a missense mutation?

Q.

Why do people with Downs syndrome have big tongues?

Q.

What is green blood?

Q.

The most striking example of point mutation is found in a disease called

1. Sickle cell anaemia

2. Down’s syndrome

3. Night blindness

4. Thalassemia

Q.

What are chromosomal disorders? Explain Downs syndrome in human beings?

Q.

What are the causes of albinism?

Q.

Can you fix chromosomal abnormalities?

Q.

2n-2 is known as:

1. Monosomic

2. Trisomic

3. Nullisomy

4. Polyploidy

Q.

Given below is a set of four terms. In this set, one term is odd and cannot be grouped into the category to which the other three belong. Identify the odd one.

Goitre, Dwarfism, Acromeg­aly, Cataract

1. Dwarfism

2. Cataract

3. Acromeg­aly

4. Goitre

Q.

What diseases are caused by point mutations?

Q. State the effects of oversecretion of the following: [3 MARKS]
(a) Thyroxine
(b) Parathormone
(c) Somatotropin

Q.

Which Chromosome Is Affected in Down Syndrome?

Q. Which among the following is not a symptom of Down's syndrome?

1. Mental retardation
2. Short life span
3. Short wide neck
4. Pink eyes

Q.

Can you fix Chromosomal abnormalities?

Q.

Are chromosomal disorders genetic?

Q. Down's syndrome is a genetic disorder.

1. True
2. False

Q. Statement 1: Genetic disorder caused by change in the molecular structure of haemoglobin is sickle cell anaemia.

Statement 2: It results in the production of sickle-shaped WBC.

1. Statement 1 is true and statement 2 is false
2. Statement 1 is false and statement 2 is true
3. Both the statements are false
4. Both the statements are true

Q. Identify the characteristics that belong to Down's syndrome.

1. Trisomy of 21st chromosome.
2. Monosomy of X chromosome.
3. Presence of 46+1 chromosomes.
4. Presence of 44+XXY chromosomes.

Q. The first instance of gene therapy was done for

1. Alkaptonuria
2. ADA deficiency
3. Down’s syndrome
4. Cystic fibrosis

Q. Write a brief note on Down syndrome. (3 Marks)

Q.

Which of these is a genetic defect related to the eye?

1. Myopia

2. Night blindness

3. Hyperopia

4. Colour blindness

Q. The difference between healthy RBCs and those affected by sickle cell anaemia is their colour.

1. True

2. False

Q. The first instance of gene therapy was done for:

1. Alkaptonuria
2. ADA deficiency
3. Down’s syndrome
4. Cystic fibrosis

Q. ______ is caused by the presence of an extra chromosome number 21.

1. Albinism
2. Down syndrome
3. Klinefelter's syndrome
4. Sickel-cell anaemia

Q. Statement 1: Genetic disorder caused by change in the molecular structure of haemoglobin is sickle cell anaemia.

Statement 2: It results in the production of sickle-shaped WBC.

1. Statement 1 is true and statement 2 is false
2. Statement 1 is false and statement 2 is true
3. Both the statements are false
4. Both the statements are true

Q. What is karyotype of feme in turner syndrome 45+xo or 44+ xo

Q. Oxygen carrying capacity of haemoglobin is reduced in which of the following diseases?

1. Albinism
2. Down syndrome
3. Sickle-cell anaemia
4. Optic neuropathy

Q. Assertion [A]: Only a boy child could be born with the substitution of glutamic acid by valine on the 6th position of haemoglobin chain.

Reason [R]: The gene for the above mutation occurs in Y chromosome.

1. Both A and R are true and R is the correct explanation of A.
2. Both A and R are true but R is not the correct explanation of A.
3. A is true but R is false.
4. Both A and R are false.