A disease caused by an autosomal primary non-disjunction isKlinefelter-s syndromeSickle cell anemiaTurner-s syndromeDown-s syndrome

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Down's Syndrome

A disease cau...

Question

A disease caused by an autosomal primary non-disjunction is

Sickle cell anemia

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Down's syndrome

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Klinefelter's syndrome

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Turner's syndrome

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Solution

The correct option is D Down's syndrome
Down's syndrome is caused due to the trisomy of 21 chromosome which is an autosome. It is mainly caused due to the non-disjunction of the chromosomes. Non-disjunction is the condition when the sister chromatids fails to seperate during the cell division.
So, the correct answer is option B.

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Similar questions

Q. The diagram represents the chromosomes of a person with a genetic disorder caused by non disjunction in which the chromosomes fail to separate properly. Which chromosome set display non-disjunction? What is the syndrome?

Assertion [A]: Klinefelter syndrome occurs only in males.

Reason [R]: Klinefelter syndrome is characterised by an additional Y chromosome in the karyotype.

Q. Match the syndromes and chromosomal abnormalities given in columns.

	List I - Syndrome		List II - Chromosomal abnormalities
A	Klinefelter syndrome	p	Trisomy 13
B	Turner's syndrome	q	Trisomy 18
C	Super female	r	44+XXY
D	Patau's syndrome	s	44+XXX
		t	44+XO

Q. Down syndrome is due to non-disjunction of

Q. Non-disjunction can be caused by

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