A type of genetic mutation that does not lead to amino acid change in protein product is known as

The correct option is E Silent mutation
The insertion of one or more nucleotide base shift the reading frame forward and deletion of one or more nucleotide base shift the reading frame which in turn changes types and sequence of amino acids. A point mutation that changes a codon specifying a different amino acid is called as the missense mutation. It can alter the protein activity to the severity that can cause a disease. A point mutation that introduces a premature stop codon, or a nonsense codon, by addition or deletion of the base, in the transcribed mRNA is a nonsense mutation. A mutation causing the no change in the amino acid and hence no effect on the function of the protein is called as silent mutation; if point mutation alters the third base of the codon, there is no change in amino acid.

Therefore, the correct answer is option E.