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Question

At a particular locus, frequency of allele A is 0.6 and that of allele a is 0.4. What would be the frequency of heterozygotes in a random mating population at equilibrium?

A
0.36
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B
0.16
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C
0.24
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D
0.48
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Solution

The correct option is C 0.48
In a stable population, for a gene with two alleles, 'A' (dominant) and 'a' (recessive), if the frequency of 'A' is p and the frequency of 'a' is q, then the frequencies of the three possible genotypes (AA,Aa and aa) can be expressed by the Hardy-Weinberg equation:
p2+2pq+q2=1
where p2= Frequency of A (homozygous dominant) individuals
q2= Frequency of aa (homozygous recessive) individuals
2pq= Frequency of Aa (heterozygous) individuals.
so, p=0.6 and q=0.4 (given)
2pq (frequency of heterozygote) =2×0.6×0.4
=0.48.

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