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Question

Both haemophilia and thalassemia are blood related disorders in humans. Write their causes and the difference between the two. Name the category of genetic disorder they both come under. [3]

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Solution

The following are the causes and difference between haemophilia and thalassemia: [1 mark for each point (any two points)]
Haemophilia ThalassemiaSingle protein involved in the clotting of blood is affectedDefects in the synthesis of globin chain lead to formation of abnormal haemoglobinSex linked recessive disorder.Autosomal recessive disorderBlood does not clot.Results in anaemia.

Both haemophilia and thalassemia are Mendelian disorders. [1]

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