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Question

Cystic fibrosis is caused due to

A
Recessive sex-linked gene on X-chromosome
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B
Recessive autosomal gene on chromosome 7
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C
Dominant sex-linked gene on X-chromosome
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D
Dominant autosomal gene on chromosome 11
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Solution

The correct option is A Recessive autosomal gene on chromosome 7
  • Cystic fibrosis is an inherited disease.
  • It is caused due to the mutation of the cystic fibrosis gene on chromosome 7.
  • The cystic fibrosis gene encodes a protein known as the cystic fibrosis transmembrane regulator (CFTR).
  • This abnormal CFTR protein in patients with cystic fibrosis leads to disruption of chloride channels on the cells.
  • It is characterized by the production of abnormal mucus that is excessively thick and sticky.
  • It affects the secretory glands, lungs, pancreas, liver, intestines, sinuses, and sex organs.

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