During bleeding phase of menstrual cycle, unfertilized secondary oocyte undergoes autolysis. The interplay of hormone then is:

Progesterone and estrogen continue the hypertropy of endometrial lining

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Prolactin and progesterone reduces LH level causing regression of corpus luteum

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Progesterone inhibits the release of LH from causing regression of corpus luteum

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Prolactin and estrogen inhibits progesterone secretion leading to sloughing off of uterine lining

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Solution

The correct option is C Progesterone inhibits the release of LH from causing regression of corpus luteum
If fertilization does not occur, the secondary oocyte undergoes autolysis and progesterone (secreted by persistent corpus luteum) inhibits the release of LH. Reduction of LH level causes regression of corpus luteum by autolysis and thus, a gradual fall in the progesterone level in the blood. Due to deficiency of progesterone, uterine lining sloughs off causing bleeding.

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