Identify the correct statements from the following
(A) Individuals with Kartagener’s syndrome lack dynein protein
(B) Cystic fibrosis is an autosomal dominant disorder
(C) Sickle cell anemia is an example of pleiotropism in humans
(D) Phenylalanine hydroxylase converts phenylalanine to tyrosine in the spleen

Choose the correct option:

The correct option is C A and C
Kartagener’s syndrome is an autosomal recessive trait characterized by situs inversus (lateral disposition of viscera) and lack of dynein protein in all ciliated and flagellated cells.

Cystic fibrosis is an autosomal recessive disorder where chloride ion channels dysfunctioning leads to the production of thick mucus which plugs the tubes and tract in lungs, liver pancreas and exocrine glands etc.

In sickle cell anemia, 𝛃- chain of haemoglobin gets mutated at the $6^{\mathrm{th}}$ position (substituting valine in place of glutamic acid) which distorts the R.B.Cs structure.

Phenylketonuria is an autosomal recessive disorder. The homozygous recessive individuals lack an enzyme called phenylalanine hydroxylase which converts phenylalanine to tyrosine in the liver. The absence of this enzyme leads to the accumulation of phenylalanine in the body causing skin pigmentation, mental retardation, and loss of hair.

Thus among the given, ‘A’ and ‘C’ are correct statements.