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Question

If both parents are carriers for thalassaemia, which is autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child?

A
25%
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B
100%
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C
No chance
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D
50%
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Solution

The correct option is A 25%
Suppose, N is the normal gene and NTis the carriers gene for thalassaemia.
Gametes from parents N NT
N NN
NNT
NT NNT NTNT

Since thalassaemia is autosomal recessive disorder, the chances (percentage) of pregnancy resulting in an affected child
= 14 × 100%
= 25%

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