If immunoglobulin IgG was papain digested, which of the following parts of it can not be observed in the screening
I. Fab
II. Fc
III. F(ab) $_{2}$

I and II

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II and III

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III only

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II only

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Solution

The correct option is C III only
If IgG is subjected to papin digestion- 2 identical Fab fragments, which are monovalent in nature and 1 Fc regions are obtained.
In contrast, divalent antibody fragments F(ab)2 are generated by pepsin digestion, not papain.

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If immunoglobulin IgG was papain digested, which of the following parts of it can not be observed in the screening I. Fab II. Fc III. F(ab)2

The correct option is C III onlyIf IgG is subjected to papin digestion- 2 identical Fab fragments, which are monovalent in nature and 1 Fc regions are obtained. In contrast, divalent antibody fragments F(ab)2 are generated by pepsin digestion, not papain.

If immunoglobulin IgG was papain digested, which of the following parts of it can not be observed in the screening
I. Fab
II. Fc
III. F(ab) $_{2}$

The correct option is C III only
If IgG is subjected to papin digestion- 2 identical Fab fragments, which are monovalent in nature and 1 Fc regions are obtained.
In contrast, divalent antibody fragments F(ab)2 are generated by pepsin digestion, not papain.