In 2012, Ryan Clark of the Pittsburgh Steelers was forced by his coach to sit out of a playoff game in Denver due to health concerns. Clark is a heterozygote for sickle cell anemia.
Sickle cell anemia is a recessive condition that results in misshapen red blood cells due to a mutation in the hemoglobin gene. The condition greatly reduces the ability of red blood cells to carry oxygen.
Heterozygotes generally do not have symptoms of the condition, but will sometimes have problems when dehydrated or at high altitudes. In addition to reduced oxygen carrying ability, the sickle cell allele has another trait; resistance to malaria.
Some areas of the world have a sickle cell allele frequency of up to nearly 20%. What would you expect to find in areas of the world with high sickle cell frequencies?
In 2012, Ryan Clark of the Pittsburgh Steelers was forced by his coach to sit out of a playoff game in Denver due to health concerns. Clark is a heterozygote for sickle cell anemia.
Sickle cell anemia is a recessive condition that results in misshapen red blood cells due to a mutation in the hemoglobin gene. The condition greatly reduces the ability of red blood cells to carry oxygen.
Heterozygotes generally do not have symptoms of the condition, but will sometimes have problems when dehydrated or at high altitudes. In addition to reduced oxygen carrying ability, the sickle cell allele has another trait; resistance to malaria.
Some areas of the world have a sickle cell allele frequency of up to nearly 20%. What would you expect to find in areas of the world with high sickle cell frequencies?
The correct option is C Low rates of malaria
Individuals heterozygous for sickle cell may face certain conditions in higher altitudes and under dehydration. Apart from this it provides resistance against Malaria, this occurs due to drop in oxygen levels in the infected RBCs which in heterozygotes creates sickle cell like condition, that leads to removal and destruction of infected RBCs from the circulation preventing spread of the infectionSo, the correct answer is 'Low rates of malaria'
Individuals heterozygous for sickle cell may face certain conditions in higher altitudes and under dehydration. Apart from this it provides resistance against Malaria, this occurs due to drop in oxygen levels in the infected RBCs which in heterozygotes creates sickle cell like condition, that leads to removal and destruction of infected RBCs from the circulation preventing spread of the infection
