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Question

In gene therapy, .......... can be treated by gene DNase.

A
Pituitary dwarfism
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B
Hepatitis -B
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C
Hemophilia
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D
Cystic fibrosis
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Solution

The correct option is C Cystic fibrosis
  • Cystic Fibrosis is a disease that affects the lungs. It is an autosomal recessive disease characterized by the excess secretion of thick and sticky mucus in the lungs.
  • A mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to cystic fibrosis.
  • This disease can be treated by gene therapy using the enzyme DNase that is a DNA-breaking enzyme.
  • This enzyme breaks the DNA strands of the mucus generating cells thereby reducing muscus viscosity in the lungs of such patients.
  • Hence this process of gene therapy decreases the mucus generation in the lungs.
    Thus the correct answer is option D.

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