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Inheritance of Autosomal Recessive Disorders

In sickle cel...

Question

In sickle cell anaemia, glutamic acid is replaced by valine. Which one of the following triplets codes valine?

A

G A A

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B

A A G

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C

G G G

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D

G U G

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Solution

The correct option is D
G U G

In sickle cell anaemia, base substitution from glutamic acid to valine occurs at the relevant portion of the beta chain of the haemoglobin molecule. This substitution occurs due to the single base substitution at the sixth codon of the beta globin gene from GAG to GUG.

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Similar questions

Q. In sickle cell anaemia glutamic acid is replaced by valine. Which one of the following triplets codes for valine?

Q. Identify the triplet code for valine that replaces glutamic acid in hemoglobin & leads to sickle cell anemia.

Q. Amino acid substituted in sickle cell anaemia is

Q. Assertion :Phenylketonuria and sickle-cell anaemia are autosomal recessive traits disorder.
Reason: In phenylketonuria due to lacks of phenylalanine hydroxylase AA-tyrosine is converted into phenylalanine (AA) while in sickle-cell anaemia valine is replaced by glutamic acid in

β

H b^{c} H b^{S^{C}}

,is homozygous condition of sickle cell anaemia. Reason: It occurs due to substitution of glutamic acid by valine at 6th position of

β

-chain of haemoglobin.

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Inheritance of Autosomal Recessive Disorders

Standard XII Biology

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