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Question
In sickle cell anaemia, the sequence of amino acids from first to seventh position of β-chain of haemoglobin S (HbS) is _______________.
In sickle cell anaemia, the sequence of amino acids from first to seventh position of β-chain of haemoglobin S (HbS) is _______________.
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Solution
The correct option is E Val, His, Leu, Thr, Pro, Val, Glu.
Sickle cell
anaemia is an autosomal disorder. It is
the most common genetical disorder appear in Africans. The disease is due to
the substitution of sixth codon in gene coding for the b-chain of Haemoglobin. Due to this,
sixth amino acid in b-chain of Haemoglobin Glutamic acid
is replaced by valine. The sequence of
amino acid is Valine – Histidine – Leucine – Threonine – Proline – Valine – Glutamic
acid.The main symptom of this disorder is decrease of oxygen uptake.
So,
the correct option is ‘Val, His, Leu, Thr, Pro, Val, Glu’.
Sickle cell anaemia is an autosomal disorder. It is the most common genetical disorder appear in Africans. The disease is due to the substitution of sixth codon in gene coding for the b-chain of Haemoglobin. Due to this, sixth amino acid in b-chain of Haemoglobin Glutamic acid is replaced by valine. The sequence of amino acid is Valine – Histidine – Leucine – Threonine – Proline – Valine – Glutamic acid.The main symptom of this disorder is decrease of oxygen uptake.
So, the correct option is ‘Val, His, Leu, Thr, Pro, Val, Glu’.Suggest Corrections
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