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Standard XII
Biology
Corticoids
Is C-peptide ...
Question
Is C-peptide present in mature insulin?
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Solution
Insulin:
Insulin is a hormone made by the pancreas that allows the body to use sugar from carbohydrates for energy.
It is released into the bloodstream to lower the level of glucose in the blood.
Presence of C-peptide in insulin:
Insulin is synthesized as a prohormone in mammals which needs to be processed before becoming a fully functional hormone.
Pro-insulin has an extra stretch called the C-peptide.
The C-peptide is removed when it matures into insulin.
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Select the true statements from the following:
(a) Insulin from animal source, may develop allergy in some patients
(b) C-peptide is not present in mature insulin
(c) Recombinant therapeutics do not induce unwanted immunological response
(d) Insulin can be administered orally to diabetic patients
Q.
Statements related to human Insulin are given below. Which statement(s) is/are correct about genetically engineered Insulin?
(a) Pro-hormone insulin contain extra stretch of C-peptide
(b) A-peptide and B-peptide chains of insulin were produced separately in E.coli, extracted and combined by creating
disulphide bond between them
(c) Insulin used for treating Diabetes was extracted from Cattles and Pigs
(d) Pro-hormone Insulin needs to be processed for converting into a mature and functional hormone
(e) Some patients develop allergic reactions to the foreign insulin
Choose the most appropriate answer from the options given below:
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Peptide A and peptide B is linked by how many disulfide linkages in insulin?
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Read the following statements carefully and select the correct option.
Statement I: Insulin is produced by alpha cells of islets of Langerhans.
Statement II: During maturation of insulin from proinsulin, C peptide is removed for proper folding.
Q.
C-peptide of human insulin is _________________.
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