Match the following:

$\begin{array}{cccc}& \text{List-I}& & \text{List-II}\\ \text{A}& \text{Down's syndrome}& \text{P}& \text{An additional sex chromosome}\\ \text{B}& \text{Cri-du-chat syndrome}& \text{Q}& \text{Loss of a part of chromosome}\\ \text{C}& \text{Klinefelter's syndrome}& \text{R}& \text{Absence of sex chromosome}\\ \text{D}& \text{Turner's syndrome}& \text{S}& \text{Presence of an extra chromosome}\\ & & \text{T}& \text{Presence of two extra chromosome}\end{array}$

The correct option is A A-S, B-Q, C-P, D-R
Down’s Syndrome: The cause of this genetic disorder is the presence of an additional copy of the chromosome number 21 (trisomy of 21). The affected individual is short statured with small round head, furrowed tongue and partially open mouth, palm is broad with characteristic palm crease. Physical, psychomotor and mental development is retarded.

Cri-du-chat (cat's cry) syndrome: Also known as 5p minus syndrome, is a chromosomal condition that results when a part of chromosome 5 is lost (missing). Infants with this condition often have a high-pitched cry that sounds like that of a cat.

Klinefelter’s Syndrome: This genetic disorder is also caused due to the presence of an additional copy of X chromosome (sex chromosome) resulting into a karyotype of 47, XXY. Such an individual has overall masculine development, however, the feminine development (development of breast, i.e., Gynaecomastia) is also expressed. Such individuals are sterile.

Turner’s Syndrome: Such a disorder is caused due to the absence of one of the X chromosomes (sex chromosome), i.e., 45 with X0, such females are sterile as ovaries are rudimentary besides other features including lack of other secondary sexual characters.