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Question

Number of Barr bodies in human female suffering from Down's Syndrome would be

A
3
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B
1
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C
2
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D
Zero
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Solution

The correct option is D 1
The presence of full or partial extra three copies of chromosome 21 causes Down syndrome. It is called as trisomy 21 and is represented as 45+XY or 45+XX. As we know that human females have two copies of X chromosome while the male has only single copy. To compensate the dosage of X-linked genes in human male and female, one X-chromosome in females is deactivated and is present as darkly stained body near nuclear envelope. The number of Barr bodies is always one less than the total number of X chromosomes. Since, Down syndrome does not affect the number of X-chromosome; a female with this syndrome will have 1 barr body. This is because the human female has two X-chromosome. To have 3, 2 and 0 Barr body, a female should have 4, 3 and 1 X chromosome respectively; this makes option A, C and D wrong. The correct answer is A.

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