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Question

Select the correct bases of DNA, RNA and amino acid of β-chain resulting in sickle cell anaemia.


A
DNA RNA Amino acid
CTC/GAG Glutamic acid
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B
DNA RNA Amino acid
CAC/GUG Valine
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C
DNA RNA Amino acid
CAC/GTG Valine
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D
DNA RNA Amino acid
CTC/GAG Valine
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E
DNA RNA Amino acid
CAC/GUG Glutamic acid
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Solution

The correct option is B DNA RNA Amino acid
CAC/GUG Valine
Sickle cell disease is a group of disorders that affects haemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have a typical haemoglobin molecules called haemoglobin S, which can distort red blood cells into a sickle, or crescent, shape. The codon on DNA is CAC the complimentary RNA has the codon GUG which leads to formation of amino acid valine.

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