Sickle-cell anaemia is caused

when valine is replaced by glutamic acid in the beta polypeptide chain

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when glutamic acid is replaced by valine in the beta polypeptide chain

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when glutamic acid is replaced by valine in the alpha polypeptide chain

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when valine is replaced by glutamic acid in the alpha polypeptide chain

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Solution

The correct option is B when glutamic acid is replaced by valine in the beta polypeptide chain
In sickle-cell anaemia, the RBCs become sickle-shaped. It is caused due to point mutation (substitution) in the gene that codes for beta haemoglobin chain. Due to this mutation glutamic acid is replaced by valine at the 6th position of the beta haemoglobin chain.

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