Sickle cell anaemia is due to

Deficiency of vitamin B.

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Deficiency of iron in the blood.

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A genetically determined defect of haemoglobin synthesis.

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Increase in the number of leucocytes in the blood.

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Solution

The correct option is B A genetically determined defect of haemoglobin synthesis.
Sickle cell anemia is the serious disorder in which the body makes sickle-shaped red blood cells. RBCs contain hemoglobin which carries oxygen from lungs to rest of the body. Sickle cells contain abnormal hemoglobin called sickle hemoglobin.
Thus, the correct answer is option (C), 'A genetically determined defect of haemoglobin synthesis'.

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