Sickle cell anaemia is more common in South Africa. This is due to

The correct option is A

Change in beta-chain of haemoglobin

Sickle cell anaemia is a disorder of the blood caused by an inherited abnormal hemoglobin. The abnormal hemoglobin causes distorted (sickled) red blood cells. Sickle cell anaemia is caused by a single gene mutation in the sixth place of the β− chain of haemoglobin where glutamic acid is replaced by valine.