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Question
Sickle cell anemia is:-
Sickle cell anemia is:-
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Solution
The correct option is C Caused by a change in a single base pair of DNA
Hemoglobin has four protein subunits, two α-globin and two β-globin. The Hbb gene codes the β-chain. Missense mutation, replacement of A by T at the 17th nucleotide of the Hbb gene changes the codon GAG (glutamic acid) to GTG (which encodes valine). The mutated allele Hbs encodes the abnormal haemoglobin molecules which stick to one another and cause stiffness and sickle shape of red blood cells. The haemoglobin-β gene is located on chromosome 11 (autosomal) and the heterozygotes have normal RBCs which means that disease is governed by the recessive gene.Thus, the correct answer is option C.
Hemoglobin has four protein subunits, two α-globin and two β-globin. The Hbb gene codes the β-chain. Missense mutation, replacement of A by T at the 17th nucleotide of the Hbb gene changes the codon GAG (glutamic acid) to GTG (which encodes valine). The mutated allele Hbs encodes the abnormal haemoglobin molecules which stick to one another and cause stiffness and sickle shape of red blood cells. The haemoglobin-β gene is located on chromosome 11 (autosomal) and the heterozygotes have normal RBCs which means that disease is governed by the recessive gene.
Thus, the correct answer is option C.
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