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Question

Terminal oxidation comprises

A
Synthesis of metabolic water
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B
Electron transport
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C
Oxidative phosphorylation
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D
All the above
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Solution

The correct option is B All the above
The respiratory breakdown of glucose in the presence of oxygen is an oxidative process. During this process, several intermediates such as pyruvic acid, isocitric acid, succinic acid and oxalic acid are oxidized. Each oxidation step involves the release of 2 H which goes to reduce various coenzymes i.e. NAD+ and FAD. Reduced NAD+ and FAD released in the glycolysis and Krebs cycle finally reduce oxygen to water. This transfer of H+ and e- from NADH + H+ or FADH2 to oxygen is not a simple process and the direct transfer of electrons from coenzymes to oxygen is thermodynamically not possible. To facilitate this transfer, many intermediate cytochromes and other carriers are arranged in a series which transport electrons from NADH or FADH2 to oxygen. This sequence of electron carriers constitutes electron transport system. The electron transport proceeds from carriers that have low redox potential to those having high redox potential. The electron transport down to the energy gradient through electron transport system leads to the formation of ATP from ADP and inorganic phosphate. This generation of ATP is called oxidative phosphorylation.
Thus, the correct answer is option D.

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