The DNA is wrapped around histone octamer and it appears as beads-on-string when seen under electron microscope. These beads in chromatin fibre further

uncoils to open DNA for cellular functions

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coils and condenses at metaphase to form chromosome

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coils and condenses to form nucleosome

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uncoils to form nucleosome

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Solution

The correct option is B coils and condenses at metaphase to form chromosome
DNA is negatively charged and histone proteins are positively charged. The DNA is wrapped around histone octamer. DNA wraps in such a way that it appears as beads on string. These small units or beads are nucleosomes consisting of DNA and histone octamer. These beads on string are packed to form chromatin fibre which further coils and condenses at metaphase stage of cell division to form chromosomes.

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What are the structures called that give an appearance as ‘beads on a string’ in the chromosomes when viewed under an electron microscope?

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