The handpicking method is useful for the separation of two substances which are bigger in size and are visibly different.

The correct option is A True
Handpicking is a seperation technique used to separate substances from the mixture by hand. It involves simply picking out substances by hand and separating them from others. Handpicking method can be used when items differ on the basis of color, shape and weight.
Examples: separating stones from rice, separating pencils from colour pencils, etc.