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Question

The Human Immunodeficiency Virus, HIV, is a retrovirus that contains RNA as the genetic material. Scientists believe that the chimpanzee version of the immunodeficiency virus (called Simian Immunodeficiency Virus or SIV) was the original source of HIV infection in humans.
It is theorized that SIV was transmitted to humans and mutated into HIV when humans in Africa hunted chimpanzees for meat and exposed themselves to the infected blood. The mutation rate in retroviruses, including SIV and HIV, is much higher than it is among DNA viruses.
The most likely explanation for this is that
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A
DNA is more chemically stable than RNA.
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B
Retroviruses like HIV lack replication error-checking mechanisms when copying DNA from RNA, and thus have higher rates of mutation.
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C
Retroviral envelopes are able to fuse with host cell membranes, causing spontaneous changes in the viral genome.
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D
The action of host cell restriction enzymes can trigger base changes in viral RNA.
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Solution

The correct option is B Retroviruses like HIV lack replication error-checking mechanisms when copying DNA from RNA, and thus have higher rates of mutation.
Retroviruses exhibit high genetic variations. Reverse transcriptase enzyme lacks proofreading or error checking mechanisms when RNA is converted to DNA. Host cell membrane and retroviral envelope interactions cannot cause any change in the viral genome. The host cell restriction enzyme system cannot trigger any changes in viral RNA because the host cell becomes the retrovirus factory. DNA is chemically more stable than RNA but that does not account for the high mutation rates.
Hence, The correct option is B.

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