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Question

This is a pedigree for autosomal recessive disease albinism (aa). What is the probability of II – 1 being homozygous normal?


A
1/3
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B
1/2
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C
2/3
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D
1/4
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Solution

The correct option is A 1/3
In the pedigree given, both the individuals of I generation are normal, but one offspring is affected out of three. Hence the genotype of both individuals of I generation is Aa, i.e., both parents carry a copy of 'a' gene.
All the possible genotype of the II generation are:

AaAAAAaaAaaa

Therefore, there are 3 possible genotypes: AA (homozygous normal), Aa (heterozygous normal), aa (affected with albinism). We can see from the pedigree that the person (II-1) is unaffected, hence she does not have aa gene and hence we can rule out the aa instance. So, out of the remaining three intances i.e., AA, Aa and Aa, only in 1 instance the person can be homozygous normal i.e., have AA gene.
Hence, the probability of an individual being homozygous normal will be 1 (AA) out of 3 (AA, Aa and Aa)= 13.
So, the correct option is a.

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