What is the difference between frameshift mutation and point mutation?
Point change:
Frameshift change:
Difference between frameshift mutation and point mutation:
Point Mutation | Frameshift Mutation |
1. A gene mutation that involves substituting, deleting, or inserting a base pair is called a point mutation. | 1. Some chemical mutagenesis enters between the two bases of the DNA chain and results in the addition or deletion of some bases. This coding results in a side shift of the frame, from where all the codons change. Such a mutation is called a frameshift mutation. |
2. It involves transitions and changes. | 2. It involves insertion and deletion. |
3. This results in a change in the structure of the gene. | 3. It results in a change in the number of nucleotides. |
4. It causes diseases like sickle cell anemia. | 4. It causes diseases like cystic fibrosis and Crohn's disease. |