What marks the end of prophase in mitosis?

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Solution

Prophase:
Mitosis is the process of cell division in which a mother cell is split to give rise to two new daughter cells.
In the early prophase, the chromosomes condense and a mitotic spindle is formed.
The nucleolus disappears and enables to nucleus to start dividing.
During the late prophase, the chromosomes are highly condensed and the nuclear envelope is completely disintegrated.
The end of the prophase is denoted by the formation of spindle fibers and the complete dissolution of the nuclear membrane.

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