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Question

What will be the percentage inheritance of a disorder from an x-linked diseased father to his son ?
(1) 0% (2) 25% (3) 50% (4) 100%

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Solution

1)0%
an affected father who has a mutation in a gene on the X chromosome can transmit either the X chromosome with this mutation or a Y chromosome to his children. If the mother is not affected or a carrier, none of his sons will be affected since they can only inherit a normal X chromosome from their mother and they inherit a Y chromosome from their father. Each daughter will have a 50% chance of being an unaffected carrier and a 50% chance of both X chromosomes being normal.

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