Which of the following will undergo acid-base reaction with Grignard reagent ?

The correct option is D All of these
$R-X+Mg\stackrel{E{t}_{2}O}{\to }RMgX\left(\text{Grignard reagent}\right)$
Amine, alcohol and carboxylic acid all contains acidic hydrogen and grignard reagent acting as strong base take up proton to form alkane.

$A.RMgX+R^{\prime }N{H}_2\stackrel{\text{Dry Ether}}{\to }RH+MgX\left(NH{R}^{\prime }\right)$
Mechanism:


$B.R^{\prime }-\stackrel{\delta +\delta -}{OH}\underset{\text{Dry ether}}{\overset{RMgX}{\to }}RH$

$C.R^{\prime }-CO\underset{\delta -}{O}-\underset{\delta -}{H}\underset{\text{Dry ether}}{\overset{RMgX}{\to }}RH$