Which one of the following generates new genetic combinations leading to mutations

The correct option is D Sexual reproduction

• Sexual reproduction is the reproduction which is caused by the fusion of gametes. The male and female gametes fuse to form the zygote.
• Due to the fusion of gametes the product of sexual reproduction generally generates new genetic combinations leading to variations.
• The organism develops from the zygote which has characters of both the parents.
• The genome of the offspring is formed by the recombination of genetic material so they are also known as recombinants. The recombination may cause the sudden heritable change in the gene pool which causes mutations.

So, the correct answer is option D.